Here are my visual mnemonics for medications that block the action of calcitonin gene-related peptide (CGRP)—“Cerebrum Gets Really Painful” or "Cranium GRiP". CGRP has nothing to do with calcitonin functionally. CGRP is released from trigeminal ganglia cells and leads to inflammation and vasodilation. CGRP has similarities with substance P (P for pain).
2018 marked the arrival of monoclonal antibodies against CGRP (or CGRP receptors) for migraine prevention. Following were several CGRP receptor antagonists, the "-gepants", for acute treatment of migraine. CGRP receptor antagonists appear to be less effective than triptans, but they can be used in patients with vascular disease. Zavegepant (ZAVZPRET) was approved this month.
Here are 8 mascots for recollection of trade-generic name pairs. A medication mascot can serve as an anchor for subsequent facts you learn about the drug. We have 3 zooms, 1 noob, and 4 pants. Apologies to eptinezumab.
Fremanezumab (AJOVY)
Pronunciation: FREE ma nez ue mab / a JOE vee
Mechanism: monoclonal antibody against CGRP
Delivery: subcutaneous
Mnemonic phrase: “Freeman zooms (on an) Anchovy”
Galcanezumab (EMGALITY)
Pronunciation: gal ka NEZ ue mab / em GAL i tee
Mechanism: monoclonal antibody against CGRP
Delivery: subcutaneous
Mnemonic phrase: “Gal can zoom (for) Equality”
Eptinezumab (VYEPTI)
Pronunciation: EP ti NEZ ue mab / vye EP tee
Mechanism: monoclonal antibody against CGRP
Delivery: IV ("I.V.-Yepti")
Mnemonic phrase: “Epstein’s Yep T’s”
Erenumab (AIMOVIG)
Pronunciation: e REN ue mab / AIM oh vig
Mechanism: monoclonal antibody against CGRP receptors
Delivery: subcutaneous
Mnemonic phrase: “Aim (at) moving Errant noob”
Ubrogepant (UBRELVY)
Pronunciation: ue BROE je pant / ue BREL vee
Mechanism: CGRP receptor antagonist ("gepant")
Delivery: oral
Mnemonic phrase: “Yer bro’s Uber pants”
Rimegepant (NURTEC ODT)
Pronunciation: ri ME je pant / NUR tek
Mechanism: CGRP receptor antagonist ("gepant")
Delivery: oral
Mnemonic phrase: “Rhymin’ G pants are Nerd tech?”
Atogepant (Qulipta)
Pronunciation: a TOE je pant / kew LIP tah
Mechanism: CGRP receptor antagonist ("gepant")
Delivery: oral
Mnemonic phrase: “Cute lips & a toe(ga) pant”
Zavegepant (ZAVZPRET)
Pronunciation: zav eg je pant / zav spret
Mechanism: CGRP receptor antagonist ("gepant")
Delivery: Intranasal
Mnemonic phrase: “Savage print pants”
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