COBENFY (xanomeline + trospium), related meds—and all things muscarinic—to understand and remember
Cobenfy, xanomeline + trospium, the next-generation antipsychotic is 9 out of 10 a big deal. Understand in context of all things muscarinic
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Jason Cafer MD
May 171 min read
Dr Cafer interview on Precision Health & PGX Podcast
Sneak peak of Cafer's Psychopharmacology 2nd Edition: Medication Mascots, Avatars, and Ballicules (2025)
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Jason Cafer MD
May 142 min read
Interaction of the week: Fluoxetine (Prozac) + Amitriptyline
Fluoxetine ↑ amitriptyline x2 and nortriptyline metabolite x9. The danger is arrhythmia. 5-HT toxicity Sx would not be life threatening.
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Jason Cafer MD
Apr 243 min read
Is Kratom an Herbal Tramadol?
The closest prescribable comparison to MG may be the atypical opioid tramadol (Ultram). Tramadol is a weak opioid receptor agonist and SNRI.
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Jason Cafer MD
Mar 143 min read
BupropiDex is not Auvelity
It's just the dex. This info is intended for prescribers. Auvelity (dextromethorphan hydrobromide + bupropion ER) was approved as a...
1,323 views0 comments
Jason Cafer MD
Aug 12, 20233 min read
Omeprazole (Prilosec) mnemonics, interactions and risk of dementia
Medical mnemonics for omeprazole
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Jason Cafer MD
Aug 11, 20231 min read
Interaction of the week: Olanzapine (Zyprexa) + Carbamazepine (Tegretol)
Pharmacokinetic Interaction Carbamazepine may decrease the serum concentration of olanzapine by about 50% (25%-71%) by inDuction of...
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Jason Cafer MD
Aug 8, 202316 min read
Understanding Alpha-2 Agonists: mascots and ballicules for NE, clonidine, dexmedetomidine, etc.
Norepinephrine – endogenous neurotransmitter, α1 > α2 > β receptor agonist Clonidine – imidazoline > α2 receptor agonist Guanfacine –...
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Jason Cafer MD
Aug 4, 20232 min read
Interaction of the week: Mirtazapine (Remeron) + Clonidine
Explanation of the interaction between mirtazapine (Remeron) and clonidine (Catapres)
1,397 views2 comments
Jason Cafer MD
Jul 29, 20231 min read
Interaction of the week: Atomoxetine (Strattera) + Bupropion (Wellbutrin)
Atomoxetine (Strattera) + Bupropion (Wellbutrin) is a treacherous ADHD combo. I don't prescribe these two together, but it may be...
10,067 views1 comment
Jason Cafer MD
Feb 5, 20232 min read
Never accelerate lamotrigine titration (and know the UGT interactions)
This post was inspired by the Carlat Podcast: Psychopharm Commandment 4: Lamotrigine Rash. When is it advisable to accelerate the...
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Jason Cafer MD
Jun 3, 20213 min read
Viloxazine (QELBREE)
If you've subscribed to the PDF of Cafer's Psychopharmacology, now's the time to re-download for bonus content. Qelbree is a strong...
1,346 views1 comment
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