Jason Cafer MDSep 307 min readCOBENFY (xanomeline + trospium), related meds—and all things muscarinic—to understand and rememberCobenfy, xanomeline + trospium, the next-generation antipsychotic is 9 out of 10 a big deal. Understand in context of all things muscarinic
Jason Cafer MDJul 98 min readDonanemab (KISUNLA) FDA-approved for Alzheimer's: Should we recommend it?Antibody vs N3pG Aβ is relatively safe but effect size in improved functioning may not be clinically significant, brain atrophy is a concern
Jason Cafer MDAug 26, 20232 min readDonepezil (ARICEPT) mascotMedical mnemonics for donepezil (Aricept) including drug-drug interactions
Jason Cafer MDFeb 26, 20233 min readAllopurinol for bipolar mania / The brain on uric acidNew medication mascot for allopurinol, which can be used off-label as adjunctive treatment of bipolar mania
Jason Cafer MDFeb 12, 20233 min readEyeball lithium levels and suicide / Why not 150 mg?Lower micro-lithium levels appear to be associated with suicide. Why not prescribe lithium 150 mg for prevention of suicide and Alzheimer's
Jason Cafer MDJan 8, 20232 min readAlzheimer's antibody Lecanemab (LEQEMBI)LEQEMBI (lecanemab) compared to ADUHELM (aducanumab) for mild Alzheimer's disease